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If data entry is painful, then any registration forms or surveys via the phone should be avoided. It is practically impossible for users to fill out a form on a mobile phone. And as mentioned earlier, it is extremely hard to enter e-mail addresses and URLs. The smart text input found on some phones doesn t help the average user at all. It is good for power users, but that is a very small minority of phone users. The rest of us still have to hunt and peck. That means that if data entry is needed, the number of fields that are to be entered via the phone should be kept to an absolute minimum.

When the velocity is near zero and the system is nearly level, the error dynamics reduce to 0 2 D 0 g 0 VN VN 2 D VE 0 g 0 0 VE 1 N = 0 D 0 N 0 Re 1 R E 0 D 0 N E e tan( ) D 0 0 N 0 D Re bN N bE E + dN + N . (11.179) dE E dD D The observability matrix is 1 0 0 1 H 0 2 D HF = 2 D 0 HF2 A 0 0 A

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they are favored because they are associated with fewer dyskinetic motor complications and also because of a putative neuroprotective effect that is alleged to slow the progress of disease (see below) Bromocriptine, pergolide, and lisuride are synthetic ergot derivatives whose action in Parkinson disease is explained by their direct stimulating effect on dopamine (D2) receptors located on striate neurons The nonergot dopamine agonists ropinirole and pramipexole have a similar type and duration of effectiveness However, it should be pointed out that dopamine agonists are consistently less potent than L-dopa in managing the main features of Parkinson disease and, in higher doses, they produce similar side effects (see further on) Representative of studies using dopamine agonists, Rascol and colleagues reported that the use of ropinirole during the rst 5 years of illness controlled the symptoms satisfactorily and, in addition, reduced the incidence of dyskinesias compared to treatment with L-dopa.

Why dyskinesias are less frequent with ropinirole than with L-dopa is not known Some specialists attribute this simply to their lower potency All these drugs should be introduced cautiously For example, the initial dose of pramipexole is 0125 mg three times daily, following which the dosage is doubled weekly to a total of 3 to 45 mg per day if the medication is used without L-dopa Bromocriptine therapy begins at 75 to 10 mg daily in three to four divided doses, and the dosage is increased very slowly to an optimal level of 40 to 60 mg daily With all of these drugs it is possible to gradually reduce levodopa-carbidopa by about 50 percent (A dose of 5 to 10 mg of bromocriptine is approximately equivalent to 25/100 mg carbidopa/levodopa.

on CT and MRI or by tumor blush on angiography Meningiomas characteristically take the form of smoothly contoured masses, sometimes lobulated, with one edge abutting the inner surface of the skull or the falcial or tentorial dura On the CT scan they are isointense or slightly hyperintense unless enhanced by contrast infusion; calci cation at the outer surface or heterogeneously throughout the mass is common Except for the mass effect they cause, they may be dif cult to see on MRI scans performed without gadolinium The amount of edema surrounding the tumor is highly variable The CSF protein is usually elevated Treatment Surgical excision should afford permanent cure in all symptomatic and accessible surface tumors Recurrence is likely if removal is incomplete, as is often the case, but for some the growth rate is so slow that there may be a latency of many years.

) Their duration of action is slightly longer than that of L-dopa and they cause less nausea, but otherwise the action and side effects of the two drugs are much the same, as noted These medications are also undoubtedly useful in smoothing the effects of L-dopa The addition of small doses of one of these agents to a stable regimen of L-dopa in order to reduce dyskinesias requires careful titration over several weeks and a reduction of the total L-dopa dose (see further on) Our experience is in general agreement with that of Marsden, who found that of 263 patients given dopamine agonists as the sole treatment, all but 82 had abandoned medication after 6 months because of lack of effect or adverse reactions.

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